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This monograph provides comprehensive information on Meldonium (Mildronate) – whatever you do with Meldonium, you will do it many times better!

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Description

Meldonium (Mildronate) – whatever you do with Meldonium, you will do it many times better!

Chemical Composition

Meldonium, also known as Mildronate, is a synthetic analog of gamma-butyrobetaine. It is a white crystalline powder, soluble in water and various organic solvents.

Mechanism of Action

Pharmacodynamics: Meldonium acts as a cytoprotective and cardioprotective agent. It inhibits gamma-butyrobetaine hydroxylase and reduces the synthesis of carnitine, thereby decreasing the transport of long-chain fatty acids across mitochondrial membranes. This leads to a shift in cellular energy metabolism from fatty acid oxidation to glycolysis.

Pharmacokinetics: Meldonium is rapidly absorbed after oral administration. Peak plasma concentrations occur within 1-2 hours. It is predominantly excreted unchanged in urine. The half-life is approximately 4-6 hours.

Indications for Use

Meldonium is indicated for:

  • Treatment of cardiac disorders such as angina, myocardial infarction, and chronic heart failure.
  • Reduction of physical and mental stress.
  • Treatment of cerebrovascular disorders.

Contraindications

  • Hypersensitivity to meldonium or any of its components.
  • Severe hepatic impairment.
  • Pregnancy and lactation.
  • Patients under 18 years of age.

Side Effects

Common side effects include:

  • Tachycardia and arrhythmia.
  • Changes in blood pressure.
  • Headache, dizziness.
  • Dyspepsia, nausea.
  • Allergic reactions (rare).

Dosage and Administration

  • For cardiac conditions: 500-1000 mg per day, divided into two doses.
  • For cerebrovascular disorders: 500 mg per day.
  • Treatment duration typically ranges from 4 to 6 weeks.

Additional information

Weight 0,150 kg
Dimensions 11 × 10 × 0,25 cm

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